The 7 Best Flea and Tick Prevention Products for Dogs in 2021

Keep your fury friend healthy and happy

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Best Flea and Tick Prevention Products

The Spruce

Our Top Picks
These flea prevention soft chews are delivered through your dog’s bloodstream to kill ticks and fleas before they can lay eggs.
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Offering up to 12 weeks of protection against fleas and ticks, this chew is available for both large and small breeds, 6 months and older.
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Working to kill fleas and ticks and to prevent flea development for up to 28 days, this shampoo is gentle for sensitive skin.
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This plant-based spray is formulated with certified natural peppermint and clove essential oils to kills fleas and ticks on contact.
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Applied every 30 days, this topical kills fleas, flea eggs, flea larvae, and ticks including the ones that carry Lyme disease.
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This waterproof topical treatment gives long-lasting protection for a full 30 days, killing both fleas and ticks.
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Working for up to 30 days to kill fleas, ticks, and mosquitoes on contact, this treatment can be used safely on dogs as young as seven weeks.
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Particularly if your dog spends a lot of time outdoors, it's important to make sure that they're protected from fleas and ticks (and the various diseases that they carry). But flea and tick prevention products aren’t just important for your dog’s comfort and health—they can also prevent you and your family from getting Lyme disease or another tick-borne illness.

From pills and chews to ointments and shampoos, there are plenty of options to choose from to keep your dog healthy. These treatments vary in delivery method and application frequency, so you'll want to consider what best for both your pet and your schedule. It's always a good idea to check in with your veterinarian about your specific dog's needs, based on medical history and the pests in your region. No matter which tick prevention product you choose, you should still check your dog for ticks after time outdoors.

Read on for the best tick and flea prevention options on the market today.

Best Overall: NexGard Soft Chew for Dogs

NexGard Soft Chew for Dogs
What We Like
  • Chewable formula

  • Safe to use around other pets and children

  • Effective against ticks and fleas

What We Don't Like
  • Expensive

Your pup will like NexGard as much as you do because each month he'll get his medicine as a tasty beef-flavored treat. From there, the main ingredient afoxolaner kicks in to kill fleas before they’ve had a chance to lay eggs, and ticks, including the Lone Star, black-legged, American dog, and brown dog varieties.

Nexgard is also FDA-approved to help prevent infections that cause Lyme disease. In addition to effectiveness, because the drug is delivered through your pup’s bloodstream, other benefits include that your dog can get wet immediately and it is safe for puppies as young as 8 weeks. It’s available by prescription only.

Best Oral: Bravecto Chews for Dogs

parasite prevention chews
What We Like
  • Chewable formula

  • Provides protection for up to 12 weeks

  • Kills fleas quickly

What We Don't Like
  • Doesn't kill ticks on contact

  • Not all dogs like the taste

An oral chew is a particularly good option for breeds with thick or long coats (including collies and Shih Tzus), where topicals are harder to apply correctly. Each of Bravecto's prescription-only chews provides up to 12 weeks of protection against fleas and ticks, and starts to kill fleas in just two hours. They control four tick species: black-legged ticks, American dog ticks, brown dog ticks, and Lone Star ticks. If Lone Star ticks are a concern where you live, you may want to give your pet a chew every eight weeks.

The one downside to chews is that they don’t kill parasites on contact, rather your dog must get bitten first. If Lyme disease is prevalent in your area, you should talk to your vet about having your dog vaccinated.

Best Shampoo: Adams Plus Flea & Tick Shampoo

Adams Plus Flea & Tick Shampoo
What We Like
  • Gentle, nourishing formula

  • Prevents fleas for up to 28 days

  • Pleasant scent

What We Don't Like
  • Formula is toxic to cats

  • Needs to be reapplied weekly for maximum efficiency

Kill fleas and ticks and get your dog squeaky clean at the same time with this dog shampoo from Adams. With a formula containing aloe, lanolin, coconut extract, and oatmeal, it’s gentle on both you and your pup's skin—and it smells good, too. The shampoo contains an insect growth regulator (IGR) to kill and prevent flea development for up to 28 days, though you may find you need to use it every seven to ten days for the most effectiveness. A little goes a long way, so the bottle should last you for some time.

A word of caution: the shampoo contains pyrethrin, which can be toxic to cats.

Best Natural: Vet's Best Flea & Tick Pet & Home Spray

Vet's Best Flea and Tick Home Spray
What We Like
  • Plant-based formula

  • Can be used on pets or household surfaces

  • Works against fleas, ticks, and mosquitoes

What We Don't Like
  • Must be reapplied if dog gets wet

  • Some pets are afraid of spray nozzle

If you're leery of using synthetic chemicals on or in your dog, try this plant-based spray. It’s formulated with certified natural peppermint and clove essential oils to kills fleas, flea larvae, flea eggs, ticks, and mosquitoes on contact. When spraying your dog, be sure not to miss their armpits and in between their toes, two favorite hiding spots of parasites.

It takes some trial and error to figure out how often you should spray your dog—some owners report spraying dogs daily at the start and then paring it back to weekly. You’ll also need to reapply if your dog gets wet. The formula won’t stain bedding or your furniture, and is made in the United States.

Best for Small Dogs: Sentry Fiproguard Plus for Small Dogs

Sentry Fiproguard For Dogs Plus
What We Like
  • Stops flea lifecycle

  • Waterproof after it dries

  • More affordable than comparable products

What We Don't Like
  • Not safe for cats

  • Requires scissors to open tubes

A small dog won’t need the same dose of flea and tick prevention medication, and that goes for topicals, too. This variety from Sentry is made for dogs from 4 to 22 pounds. You apply it to your dog’s back every 30 days and it works to kill fleas, flea eggs, flea larvae, ticks, and chewing lice on contact. Once it dries, your dog won’t be able to lick it off and it’s safe for your dog to get wet after a few days.

Best for Large Dogs: Frontline Plus Flea & Tick Large Breed Dog Treatment

 FRONTLINE Plus Flea and Tick Treatment for Large Dogs
What We Like
  • Waterproof after 24 hours

  • Kills fleas at all life stages

  • Snap-open tubes

What We Don't Like
  • Leaves greasy spot on dog's fur

    Not safe for cats

This topical flea and tick treatment contains fipronil, which kills adult fleas and ticks, and (S)-methoprene to kill flea eggs and larvae. After you snap open the tube and apply the formula to your dog’s shoulder blades and back, it’s stored in the oil glands to give long-lasting protection for a full 30 days. Your dog should stay dry for at least 48 hours, but after that it’s waterproof and safe around young children and other pets. Frontline has been around for 20+ years and is recommended by many vets. The large variety is intended for dogs 45 to 88 pounds.

Best for Puppies: Bayer K9 Advantix II Flea and Tick Prevention for Small Dogs

K9 Advantix II Flea and Tick Prevention for Small Dogs
What We Like
  • Safe for young puppies

  • Kills insects on contact

  • Begins working in 12 hours

What We Don't Like
  • Not safe for cats

  • Doesn't always last full 4 weeks

Not all flea and tick treatments are recommended for puppies, so it’s important to check with your vet first before purchasing one. K9 Advantix can be safely used on dogs as young as seven weeks and the small dog variety is made for dogs that weigh between 4 to 10 pounds. The topical works for 30 days and kills on contact, which means fleas, ticks, and mosquitoes don’t have to bite your pup for it to be effective. It starts killing fleas in 12 hours after application. This is not made for use on cats.

Final Verdict

Our best overall pick is the NexGard Soft Chew for Dogs (view at Chewy), which is as tasty as your pup's favorite treat and works well to kill fleas before they've had a chance to spread infection.

If you are looking for a plant-based option, we recommend Vet's Best Flea & Tick Pet & Home Spray (view at Amazon). Formulated with certified natural peppermint and clove essential oils, this spray kills fleas, flea larvae, flea eggs, ticks, and mosquitoes on contact.

What to Look for in a Flea and Tick Prevention Product

Delivery method

There are several types of flea and tick prevention products that are popular today, including topicals, oral tablets, shampoos, and collars. Topical formulas are a liquid that's applied to the back of your dog's neck, while oral tablets are designed to be eaten—oral medications are preferable if your dog frequently gets wet, which can wash off topical treatments, but they're often more expensive than topicals. Shampoos often need to be reapplied several times per month.

Although the EPA continues to approve their use, at this time we are not recommending any flea and tick prevention collars due to reports about health concerns associated with these products.

Active ingredients

Most flea and tick prevention products contain some type of insecticide that kills the insects. It's important to research the active chemicals in a flea/tick prevention product to see what types of insects it kills, whether it's safe to use around children and other animals, and whether it can cause negative reactions in your pet. When in doubt, it's best to talk to your veterinarian to figure out which ingredients will work best for your dog.


Different flea and tick products are effective for different lengths of time. Some need to be reapplied every week or more, while others might last several months. Not only will this affect how often you need to re-administer the treatment, but it will also dictate how much you'll spend on flea and tick treatments each year.


How can you tell if your dog has fleas?

There are several telltale signs that your dog might have fleas. If you notice that your dog is itching more than usual, particularly at its flank or above its tail, you'll want to check to see if you can spot any of these little bugs in its coat. If you part your pet's fur, you'll often be able to see "flea dirt," which looks like tiny black specks, or even black bugs that may jump away.

How can you prevent your dog from getting fleas?

In addition to using a flea and tick prevention product on your dog, there are a few ways you can reduce their risk of getting fleas. Fleas prefer to live in shaded outdoor areas with sand, leaves, or other debris, so you can help prevent fleas by keeping your grass cut short and keeping your dog from playing in areas where fleas might be hiding. You can also treat your home with diatomaceous earth, which helps to kill adult fleas.

Can most flea treatments be used on puppies?

In general, puppies should only be given flea treatments after they're weaned—typically around seven or eight weeks of age. It's important to check the age range on the flea treatment you're using to see if it's safe to use on your puppy. Your vet will also be able to recommend an appropriate treatment for your young dog.

Why Trust The Spruce?

This article was researched and written by Anne Fritz, a freelance lifestyle writer with over 20 years of experience. To make this list, she considered the size of the dog, type of treatment, and ease of use.

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Article Sources
The Spruce Pets uses only high-quality sources, including peer-reviewed studies, to support the facts within our articles. Read our editorial process to learn more about how we fact-check and keep our content accurate, reliable, and trustworthy.
  1. Lyme Disease in Dogs. Merck Veterinary Manual.

  2. Pyrethrin/Pyrethroid Poisoning in Cats. VCA Animal Hospitals.

  3. Companies Agree to Stop Selling Pet Collars Containing Pesticide to Protect Children. United States Environmental Protection Agency.

  4. Showler, Allan T et al. Lethal Effects of a Commercial Diatomaceous Earth Dust Product on Amblyomma americanum (Ixodida: Ixodidae) Larvae and NymphsJournal of Medical Entomology, vol. 57, no. 5, pp. 1575–1581, 1 September 2020. doi:10.1093/jme/tjaa082