Liver Disease in Dogs

Symptoms, Types, and Treatment

Sick dog

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The liver is responsible for several processes in a dog's body. It creates bile to aid digestion and helps rid the body of waste. The liver also helps a dog metabolize fat, protein, carbohydrates, vitamins, and minerals. Additionally, the liver filters out the toxins and waste found in foods and medications.

A dog with liver disease may have trouble performing some of these biological processes, which can lead to a really sick pet. But some liver problems are more serious than others. Learning how to spot liver issues before they become a full-blown disease can prevent liver damage and get a sick dog back to full health.

Symptoms of Liver Disease in Dogs

Many types of liver problems can appear in a dog, causing a multitude of symptoms specific to the type. However, a sick dog is easy to spot, and common signs can include lethargy, vomiting, loss of appetite, and diarrhea. Jaundice (a yellowing of eyes, tongue, or mucous membranes), is, specifically, a tell-tale sign that something is off with your dog's liver. If your dog exhibits this yellow tint and also displays a distended abdomen, an unsteady gait, or if it runs a fever or experiences seizures, call your vet immediately.

Of course, any sign of sickness may be caused by a problem in the body that is unrelated to the liver. A visit to the veterinarian will deduce the issue.

Causes and Types of Liver Disease

Liver disease has many different causes, depending on the type. And each type is unique to a particular form of the illness. Acute liver disease (or acute liver failure) refers to an issue that comes on suddenly, affecting the liver's ability to function. In some cases, part of the liver becomes necrotic (or dies). Acute liver disease can develop after exposure to a toxic substance or poison. And while some toxins directly impact the liver function, others cause different organs to fail, leading to secondary liver damage. Acute liver damage can also occur after exposure to excessive heat (don't leave your pet in a hot car!) or from an inhibited flow of fluids to the liver and surrounding tissues.

Bile duct obstruction occurs when the tubes that carry bile from the liver to the gallbladder become blocked. Generalized inflammation, an infection, a tumor, or even a disorder of the muscles that control the organs can be the culprit.

A portosystemic shunt—also called a liver shunt—happens when the blood from the stomach, intestines, pancreas, and spleen bypass the liver. This prevents the filtering out of toxins, which can then build up in the body, leading to a variety of symptoms, including seizures. A liver shunt may be present at birth or developed due to another liver problem.

Viral, bacterial, fungal, or parasitic infections can also cause chronic liver problems. Leptospirosis, for instance, is a bacteria found in the urine of rodents and wildlife. This bacteria, when ingested by an unvaccinated dog, can cause major liver damage. Chronic active hepatitis can also be caused by an infection, by toxins, or by other damage that the liver could not completely recover from.

Liver tumors and cancer, while most common in older dogs, can occur during any stage of life. And while not all tumors are cancerous and not all types of cancer manifest as a tumor, an abnormality within the liver itself, or in nearby tissue, may affect its ability to function properly.


If liver disease is suspected, a vet will order lab work to evaluate organ function. Elevated liver enzymes found in the blood—like alanine transaminase (ALT), aspartate transaminase (AST), and alkaline phosphatase (ALP)—can indicate a problem. Additionally, the blood levels of bilirubin (a substance found in bile) and albumin (a protein made by the liver) provide information about overall liver health. And a complete blood count may indicate the presence of an infection or inflammation. Abdominal imaging, like radiographs (x-rays) or an ultrasound, may reveal scar tissue and tumors in or around the liver region. If a tumor is found, your vet may recommend a biopsy to check for the presence of bacteria, cancer cells, and more.

The treatment options for acute liver disease depend on the type of toxin and the degree of damage done to the liver. Fluids and electrolytes, oxygen supplementation, and restricted activity are the recommended protocol, while severe cases may benefit from enteric or catheter feeding and a course of medication. Bile duct obstruction can sometimes be remedied with medications like ursodiol. However, for full duct obstruction, surgery is often necessary. Surgery has a high success rate for liver shunt and can be a cure for most dogs. Antibiotics and antiviral medications can be given in the presence of infection. Yet, chronic active hepatitis—not reversible or curable—is often managed with medications and a restricted diet. Treatment for liver tumors or cancer will depend on test results and may involve surgery, chemotherapy, and the administration of medications.

Medications and supplements (like Denamarin) can help many dogs with liver disease or damage live for years with minimal symptoms. In some cases, dietary changes are also necessary. The response to treatment depends on the individual dog, but compliance from the owner is a major component to success. Be sure to adhere to your vet's recommendations for medications, diet, and follow-up testing and exams.

How to Prevent Liver Disease

While keeping your dog healthy involves routine wellness exams, there are other ways to assure the health of its liver. Refrain from feeding your dog fatty foods and make sure to allow for plenty of exercise and outdoor time. Keep all toxic substances—like antifreeze and paint solvents—locked up and out of your dog's reach. And, add supplements like dandelion and apple cider vinegar to your dog's diet for a seasonal "cleanse" that assures optimal live function.