Everything You Need to Know About Puppy Vaccinations

Bulldog puppy panting in man's arms

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Vaccines are an essential part of a puppy's health care plan. Certain basic immunizations are essential to keep your puppy from getting sick and prevent the spread of disease.

Why Vaccinate Your Puppy?

When puppies are born, their immune systems are not fully developed, so they cannot fight disease. However, during the first two days of a puppy’s life, nursing mothers provide antibody-rich milk called colostrum. These antibodies provide puppies with temporary immunity against illness. While the length of this immunity varies from puppy to puppy, it is generally believed that maternal antibodies are gone after about 16 weeks of age.

Enter puppy vaccinations. Vaccines are designed to trigger immune responses and prevent future infection from diseases. All puppies should be administered certain core vaccines which provide immunity against the most dangerous and widespread diseases. Core vaccines are considered essential for puppies in most geographical locations. Depending on your location and your puppy's environment, non-core vaccines may also be recommended. Talk to your vet about your puppy’s risk of exposure to these diseases.

How They Work

Puppy vaccines are typically first administered at about six to eight weeks of age, then repeated every three to four weeks until about four months of age. Some of these vaccines might be given together in one injection that is called a combination vaccine. At your puppy's first veterinary exam, your vet will discuss the schedule of vaccinations and other treatments for your puppy, such as deworming and beginning heartworm prevention. The vaccine injection itself is typically not painful. Some puppies seem to feel a little pinch or sting while others do not react at all.

Your veterinarian will need to do an examination before vaccinating your puppy. Note that vaccines should never be given to a puppy with a fever or illness as the vaccine will not be effective and could actually make the puppy feel worse. 

After a vaccine is administered, immunity is not immediate; it takes about five to ten days to become effective. However, puppies that still have maternal antibodies will not develop immunity at all. There is no way to be certain if a puppy still has maternal antibodies, hence the reason for boosters. True immunity is uncertain until about four months of age, or until all puppy boosters are completed. Avoid bringing your puppy to dog parks or otherwise exposing your puppy to unknown animals until all vaccinations have been given. See the chart below for a typical vaccine schedule.

Puppy Vaccine Schedule (Sample):

Age Core Vaccines Non-Core Vaccines*
6 to 8 weeks Distemper, Parvovirus, Adenovirus Coronavirus, Parainfluenza
9 to 11 weeks Distemper, Parvovirus, Adenovirus Coronavirus, Leptospirosis, Parainfluenza, Bordetella
12 to 14 weeks Rabies, Distemper, Parvovirus, Adenovirus Coronavirus, Leptospirosis, Parainfluenza, Lyme, Bordetella

*Recommendation of non-core vaccines depends on your geographical location and your puppy's environment. Talk to your vet about your puppy's potential exposure.

A Note on Adult Boosters

Most vaccines require a booster within 1 year after the puppy series. There is a 3- year rabies vaccine. After that, some vaccines will need to be given annually, and others will only need to be given every 3 years.


There are some risks associated with vaccinations though relatively uncommon. Vaccine reactions and side effects are typically mild and self-limiting. Signs may include pain and swelling at the injection site, lethargy or fever. Severe allergic reactions are rare but can be fatal if left untreated. If your puppy develops hives, facial swelling, difficulty breathing, vomiting, or bloody diarrhea, contact your vet immediately.

Because vaccinations stimulate the immune system, there is a risk of developing an auto-immune disorder. This is very uncommon when you consider the numbers of dogs affected versus all the dogs that are vaccinated. However, auto-immune disorders can be serious and difficult to treat. Illnesses that may occur include blood disorders, neuromuscular issues, and even skin problems.

Despite the potential side effects, most veterinarians and pet experts agree that the benefits outweigh the risk when it comes to puppy vaccines. However, with adult boosters, many vets are embracing protocols that vaccinate less often. Once given annually, many adult vaccinations are now more likely to be recommended every three years.

If you suspect your pet is sick, call your vet immediately. For health-related questions, always consult your veterinarian, as they have examined your pet, know the pet's health history, and can make the best recommendations for your pet.

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Article Sources
The Spruce Pets uses only high-quality sources, including peer-reviewed studies, to support the facts within our articles. Read our editorial process to learn more about how we fact-check and keep our content accurate, reliable, and trustworthy.
  1. Chastant, Sylvie, and Hanna Mila. Passive Immune Transfer In PuppiesAnimal Reproduction Science, vol 207, 2019, pp. 162-170. Elsevier BV, doi:10.1016/j.anireprosci.2019.06.012

  2. 2017 AAHA Canine Vaccination Guidelines. American Animal Hospital Association, 2020

  3. What to expect after your pet's vaccination. American Veterinary Medical Foundation, 2020